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A kiss of death or a kiss of wedding? In 2022, we will witness the meeting of two stars!

If the probability that two strangers meet and fall in love in the vast sea of people is very small, how likely are the two stars in the vast universe to meet and merge?

At the just-concluded American Astronomical Society, Larry Molnar, an astronomy professor from Calvin College in the United States, released an exciting news: around March 2022, two low-quality stars in the Milky Way will merge.

As soon as the news was published, it aroused strong public interest. After all, not many humans have the opportunity to witness the merger of two stars in their lifetime.

Where are these two stars? How far is it from us? What force created this shocking collision? How many years will the merger of these two behemoths last? Dinosaurs just witnessed the encounter between a comet and a planet, and they were almost wiped out. Then, five years later, when these two stars finally collided, what wonders will we witness? What impact will this collision have on our home planet Earth?

Let’s explore it in detail and do some homework in advance for this cosmic "encounter".

Figure 1: The red dot represents the position of the merged binary system.

1800 light years away: long gestation and rapid merger

As you probably know, in our galaxy, there is a constellation Cygnus, and these two merging stars are in Cygnus. They form a star binary system called KIC 9832227, which is about 1800 light years away from us.

As early as January 2015, Professor molnar and others published relevant contents at the American Astronomical Society, and identified KIC 9832227 as a binary system that is likely to be merged.

They analyzed the data of this system from 1999 to 2014, and found that its cycle was continuously decreasing, and the decreasing trend was very similar to that before the outbreak of Scorpio V1309, and there was also a star merger event in Scorpio V1309. In 2015-2016, Professor molnar and others used further observation data to verify their previous inference, and finally confirmed that the system would be merged one day.

However, there are as many as 200 billion to 400 billion stars in the Milky Way, and nearly one third of them are located in binary or multi-star systems. It seems not uncommon for two stars in a binary system to merge.

Is this really the case? This requires us to understand the classification of binary systems first.

We can easily understand the "binary star system", that is, a system consists of two celestial bodies; These two celestial bodies can be ordinary stars or dense celestial bodies with high density, such as neutron stars or black holes.

In astronomy, we can classify binary systems according to many standards, one of which is the distance between two celestial bodies. For a "wide binary", the two celestial bodies are far apart and have little interaction. Two celestial bodies that are close to each other are called "close binaries", and it is possible for them to influence each other or transmit matter. Among the numerous binary systems in the Milky Way, there are only about 40,000 pairs of close binary stars, which can be said to be very rare.

Some close binary stars are too "intimate" and even come into contact, so we call them "contact binary". In an extreme case, the passing binary stars are so "close" that the two celestial bodies share the same external gas envelope. Generally speaking, it takes millions or billions of years for them to reach the stage of sharing the cladding, and once they enter the stage of sharing the cladding, the two stars will merge quickly, taking only a few months or years. Compared with the long years before sharing the envelope, the process of merger is like a blink of an eye, which is like a couple who have been in love for a marathon and then got married quickly after proposing marriage.

The binary star system KIC 9832227 mentioned above is in the final stage of shared cladding. According to the existing theoretical estimation, the two stars will merge in about five years.

Figure 2: (left): Imagination diagram before merger; (right): Numerical simulation diagram before merger.

The merger of binary stars will bring us a bright new star.

According to the current spectral data analysis, the mass of the two stars to be merged does not exceed 0.4 solar mass, which belongs to the category of the least mass stars we know. They look red, and the surface temperature is about two or three thousand degrees Celsius. Judging from the current observation, the two stars have not merged, and their apparent brightness is about 12 magnitude, which has completely exceeded the lowest limit that human eyes can see (6 magnitude), so we can only observe with the help of telescopes. (Magnitude is a unit used to measure the brightness of celestial bodies. The higher the brightness of stars, the lower the magnitude value; Sirius, the brightest star we see at night, is about 0 magnitude. )

The whole process of merging these two stars will last for several weeks, which is like a flash compared with their life span of 10 billion years. In this "instant", their brightness will rapidly increase by 100,000 times, and the apparent brightness can reach about 2 stars. It will look as bright as Polaris, second only to the three brightest stars we see in the northern sky: Sirius (-1 magnitude), Vega (0 magnitude) and Antares (1 magnitude).

The result of this binary merger is that there is a new bright star in our night sky for the time being, and its color is still red, so we call it "red star". This new star will exist for at least 10 billion years, so why do we say that there is a new bright star "temporarily"? Because it will only be bright for a few weeks, and then it will fade away and hide in the darkness beyond our naked eyes in the vast universe.

The gravitational wave generated by the merger of two black holes in 2015 attracted the attention of the whole world. So, will the merger of these two stars also generate gravitational waves five years later?

The answer is yes. The merger of binary stars will also release gravitational waves with a certain energy, but it is very small and almost negligible. Almost all the energy is concentrated in the electromagnetic wave, so we can only rely on traditional telescopes for observation. The gravitational wave observatory (LIGO) in the United States should not be able to detect this merger.

The merger of binary stars has brought us a bright new star. Will it also bring some dangers?

If we want to predict the impact of this event on life on earth, we need to know how much energy is released during the merger process and whether it will have any impact on the earth’s atmosphere.

There is no doubt that the merger of two celestial bodies will produce explosions and release a lot of energy at the same time, but the amount of energy released depends on the density of the merged celestial bodies. For example, the merger of two neutron stars will produce a so-called gamma-ray burst, which will release a thousand times the energy of a supernova in about 1-2 seconds and produce extremely strong gamma rays-astronomers have discussed the impact of such bursts on the earth-if such celestial bodies erupt at us not too far away in or outside the Milky Way, life on earth will be doomed.

However, we don’t have to worry that the merger of these two small stars will have any impact on life on earth. Compared with the merger of other dense celestial bodies, the energy released by the merger of these two stars is very small, even less than the energy generated by some normal stars, not to mention the energy generated by them is mainly in the optical band. We’d better watch the beautiful red star with peace of mind.

Standing on the shoulder of Scorpio V1309, waiting for the new star.

Fig. 3: Evolution of possible "Red Nova" Unicorn V838 after the explosion, observed by Hubble telescope.

Theoretically speaking, astronomers always believe that the merger of low-mass binary stars is one of the cradles for the birth of slightly larger stars. However, the real observation has only made some progress in recent decades, which is attributed to the development of some large-scale astronomical survey projects and the improvement of computer processing power. In the past decades, astronomers have observed similar explosions many times, such as M31 RV in the Large Magellanic Cloud in 1988, V4332 in Sagittarius in the Milky Way in 1994, and V838 system in Unicorn in 2002-these explosions may represent merger events, but we are not completely sure.

It was not until 2006 that humans really confirmed a binary merger. The supernova search project of the Lick Observatory found the explosion of M85 OT2006-1 in the M85 galaxy 60 million light years away from the Earth. Astronomers from the University of California, Berkeley and California Institute of Technology made a detailed analysis, and found that the explosion originated from the merger of two low-mass binary stars, which was different from other known nova explosions. However, due to the lack of monitoring information before the outbreak, we are very lack of understanding of the binary system before the merger. In this year, according to the observations, astronomers gave a name to the new star formed by the merger of binary stars: "luminous red novae".

The key to really help astronomers solve the mystery of "Red Nova" is hidden in Scorpio V1309. This system was first discovered by astronomy enthusiasts in China and Japan, and then they submitted the relevant information to the astronomical variable source monitoring organization of the International Astronomical Union. However, the detailed data of Scorpio V1309 comes from an optical gravitational lensing experiment (abbreviated as OGLE;; Optical gravity lens experiment). The project was officially started by astronomers of Warsaw University in Poland in 2001. The original intention was to monitor a large area of the sky, hoping to find celestial sources with changing brightness and discover the phenomenon of gravitational lens, so as to test some celestial bodies, such as black holes, which were originally thought to constitute dark matter. The location of Scorpio V1309 is just within the monitoring sky area of OGLE, so astronomers have obtained a large number of long-term observation data before and after the outbreak. Subsequent data analysis not only confirmed that this is a "red nova" system (a system after the merger of two stars), but also provided us with more important information, that is, how this binary system evolved with time before the merger.

It is on the basis of observation data and modeling before the merger of Scorpio V1309 system that Professor molnar and others judged the system evolution of KIC 9832227, and predicted that the "close contact" between the two stars and the final merger would take place between September 2021 and September 2022.

What are you waiting for? Go and put up a countdown card for the upcoming red star!

The video was produced by China, a popular science student, and was authorized to be published in the column "Learning Science with Xiaobian" of CCTV. Please indicate the source for reprinting.

Production: Black Hole Visitor Team Gou Lijun Huang Yue

Producer: computer network information center

Revealing the movie key extension: play a key role or icing on the cake?


Special feature of 1905 film network Not long ago, the film announced the second key extension, which triggered a hot discussion among netizens about the key extension of the film. Key extension is a way for film copyright owners to extend the validity of electronic keys, thus extending the film release time.

Looking at the domestic films with key extension, from the early days, only a few films choose to postpone the key every year, and now more than a dozen domestic films are postponed for screening every year. What are the doorways behind the doubling of the number of key extension films?



The earliest key extension in China can be traced back to "Crazy Stone" in 2006. A small-budget film can reach that box office at that time, which makes the whole market very excited. At that time in 2015, although the box office had reached a relatively high level, there were such strong imported blockbusters in the same year. monster hunt chose the key extension method and finally became the box office champion in that year.

In recent years, more and more movies have chosen to postpone their keys. In 2019, nearly 20 movies chose to postpone their keys. Nowadays, the key extension has become a hot search word in major schedules. For these movies, the key extension can increase the exposure and bring certain box office income.



The success of "monster hunt" is not a special case. At present, the top ten domestic movies in China have been extended with keys. Does this mean that key extension plays a decisive role in the box office?

Wu Yanyu, a film critic, said: "The decisive role is definitely not played, but for some films, there will still be a longer release cycle. For example, in The Battle at Lake Changjin, the word-of-mouth of the film continues to ferment after the National Day file, and even the box office grows very fast on weekdays, indicating that a large number of viewers know about the film’s release, but they haven’t had time to see it yet. At that time, the key extension time was quite long. The data showed that the final key extension time brought more than 300 million box office to Wolf Warriors 2, which still accounted for a certain proportion of the total box office of more than 5 billion. "



Interestingly, all the top ten domestic movies in China have been extended with keys, but this does not mean that the key extension is the decisive factor for them to become the top ten box office in film history, because these movies have their own basic discs at the box office, which makes the key extension play a role of extra points. When most filmmakers decide whether to extend the key, they will make a calculation of the box office trend. If the box office of the film is already in a relatively downward or even basically no state, there is no need to extend the key for this film.



Nevertheless, many filmmakers have made efforts and attempts. For example, this year’s very high-quality domestic animated film "Dick Pig" has been extended, and some other literary films have also made the same choice.

Wu Yanyu said: "According to the current data, the key extension obviously did not play a role in promoting the box office. On the other hand, if the cinema release time is extended, it means that the window period of streaming media on the film will be longer and the distribution cost of getting new media will be relatively reduced. According to different films, some art films may be released for a short time, and the audience’s word of mouth has not sunk into the audience that should be there. At this time, if you judge that there is still a chance to take a shot and try. "



The program interviewed the cinema manager and asked them about the key extension. Ou Bowen, general manager of Perfect World Co., Ltd. mentioned: "In theory, basically all movies can extend the key, but I personally think this is only suitable for high-quality movies. For example, The Battle at Lake Changjin’s key extension in the past two months is really a stimulus to the film market, which has been greatly improved. The current movie cycle should be week by week, and new movies are released every Monday to Friday. The release of new films will squeeze into the film arrangement space of old films. Unless the schedule environment has certain particularity, it is possible that after the film is postponed, there is still no good film to compete, and the postponed film itself is very high-quality. It is possible to achieve an ideal film arrangement effect, but the probability of this happening is not great. "



It can be seen from all aspects that the extension of the key has no direct impact on the film’s arrangement and box office. Usually, the news of the extension of the key released by the film side is often a statement picture, which is often ignored by many viewers, which also leads to the limited effect of the extension on many films. How to make better use of key extension and maximize its value?

Wu Yanyu mentioned: "In the second and third months, the film should reach the audience who are particularly sinking, and stimulate those who don’t walk into the cinema every day, but are willing to support domestic films if they see something they like. This is a long-term proposition, which may be particularly applicable to films that choose a key extension."



As a means, key extension is only icing on the cake after all. To win the audience and box office, the most important thing is the quality of the film itself. Whether it can stimulate the audience, stimulate their empathy and make the audience feel that it is the right thing to go into the cinema to support the film, which is the root of the film becoming an explosion. It takes hard work to strike while the iron is hot. May the creators polish their works and win by quality.


Peking Union Medical College Hospital Aid Hubei Medical Team: There are no conditions to create conditions and try every means to treat patients.

  Cctv newsOn May 5th, the joint prevention and control mechanism of the State Council held a press conference on the situation that the medical team of Peking Union Medical College Hospital assisted Hubei in fighting the epidemic.

  William Hinton, vice president of Peking Union Medical College Hospital and leader of the medical aid team in Hubei, said that according to the division of labor, the medical team of Peking Union Medical College Hospital is in charge of the intensive care unit in the Sino-French New Town Campus of tongji hospital, Wuhan, and all the patients admitted are critically ill patients transferred from other hospitals and other wards, who are dying in the common people’s words. Compared with Beijing rear ICU, the difficulties are mainly reflected in three aspects: first, the critically ill patients of COVID-19 patients have respiratory failure that is difficult to correct after the end stage, and many patients are complicated with multiple organ and multiple system failure; Second, the work intensity is high. At most, 18 patients are admitted in one night, that is, more severe patients are transferred to ICU at the same time in a unit time than usual. At the peak, the ventilator in the whole ward is not enough, and the oxygen pressure is not enough. Third, after the players put on protective clothing, the routine operation, treatment and rescue are more difficult and inconvenient. However, everyone did not back down, and tried every means to make every effort. There was no condition to create conditions, and all the means and methods should be used.

National Health Commission: Since the implementation of the national regional medical center construction project, more than 1,400 diagnosis and treatment technologies have been translated to the impo

  CCTV News:On April 13th, National Health Commission held a press conference on the expansion and sinking of high-quality medical resources and the balanced distribution of regions. Da-chuan Li, deputy director of the Department of Medical Administration of the National Health and Wellness Commission, introduced at the conference that since the 12th Five-Year Plan, the State Council has made the work arrangement of setting up "double centers" in nearly three health development and five-year plans of the medical and health system. At present, the establishment and construction of "Double Centers" have been written into the Law on Basic Medical Care and Health Promotion, the 14th Five-year Plan for National Economic and Social Development and the Outline of Long-term Goals in 2035, and included in the special "14th Five-Year Plan" issued by the State Council. Up to now, the National Health and Wellness Commission has set up 13 national medical centers in professional categories and national regional medical centers in children’s categories according to procedures. At the same time, the National Health and Wellness Commission and the National Development and Reform Commission approved 76 national regional medical center construction projects in four batches in areas with weak medical resources.

  After years of hard work, the National Medical Center and the National Regional Medical Center mobilized and aggregated local governments, universities, scientific research institutions and other forces, carried out in-depth core technology research, focused on solving long-term and overall medical problems affecting people’s health, and produced a number of groundbreaking clinical research results. In 2022 alone, the "Double Center" launched 372 international and domestic pioneering and leading technologies. Since the implementation of the national regional medical center construction project, more than 1,400 diagnosis and treatment technologies have been transferred to the imported provinces, filling the gaps in more than 300 provincial medical technologies, and the number of people seeking medical treatment in relevant provinces has dropped significantly.

National customs: building a port quarantine defense line. New diseases are only one flight away.

  From January to July this year, 12,565 cases of infectious diseases were detected by the national customs entry quarantine, up by 8.62% year-on-year. Zika virus disease and Chikungunya fever were detected for the first time, and cholera, Zika and other major infectious diseases were detected many times. However, traditional infectious diseases such as plague, cholera and yellow fever break out from time to time all over the world, and new infectious diseases such as Ebola hemorrhagic fever, Middle East respiratory syndrome and Zika virus disease are constantly emerging, which may become "black swan" and "grey rhinoceros" in the field of infectious diseases at any time, bringing severe challenges to global public health and China Customs.

  "At present, the global public health situation is very complicated and severe. The accelerated development of global trade, the more convenient transportation network and the more frequent personnel exchanges make there is only one flight distance between any new disease and the transmission area. " Zhang Jiwen, deputy director of the General Administration of Customs, said at the scene of an emergency drill for public health emergencies at ports recently held in Chongqing.

  The reporter of "Legal Daily" learned from the General Administration of Customs that from January to July this year, 12,565 cases of infectious diseases were detected by the national customs entry quarantine, an increase of 8.62% year-on-year. Zika virus disease and Chikungunya fever were detected for the first time, and major infectious diseases such as cholera and Zika were detected many times. However, traditional infectious diseases such as plague, cholera and yellow fever break out from time to time all over the world, and new infectious diseases such as Ebola hemorrhagic fever, Middle East respiratory syndrome and Zika virus disease are constantly emerging, which may become "black swan" and "grey rhinoceros" in the field of infectious diseases at any time, bringing severe challenges to global public health and China Customs.

The epidemic situation is unprecedentedly grim.

  In the development of human history, the struggle against infectious diseases is an eternal main line.

  Infectious diseases, such as smallpox, plague and cholera, have spread widely all over the world, causing hundreds of millions of casualties, which has seriously disrupted social order and affected social and economic development.

  According to Adrian Xu, director of the Department of Health and Quarantine of the General Administration of Customs, in the 21st century, the impact of various infectious diseases has not decreased with the growth of the world economy and the improvement of people’s living standards, but with the improvement of the world transportation facilities, the epidemic situation of infectious diseases has spread rapidly around the world. In recent years, the global epidemic situation of infectious diseases has broken out one after another, with one or two new and recurrent infectious diseases appearing every year. The outbreak frequency is getting denser and denser, the scope is getting wider and wider, the harm degree is getting deeper and deeper, and the import risk is getting bigger and bigger, which makes the global public health situation unprecedented.

  In 2014, the Ebola outbreak broke out in three African countries, causing fear and travel restrictions that almost paralyzed the whole world.

  In 2015, a business traveler infected with Middle East Respiratory Syndrome virus returned to South Korea, quickly infecting 186 people, killing 38 people and isolating 17,000 people, which led to the disorder of health system and society in South Korea. South Korea’s exports fell by 10.9% year-on-year, and the president was forced to cancel his visit to the United States. The epidemic also spread to China.

  In 2016, after 60 years of silence in Africa and Asia, Zika virus disease suddenly became popular in Brazil and continued to spread across borders. Because Zika virus can cause neonatal microcephaly, the World Health Organization declared it a public health emergency of international concern.

  In July this year, the World Health Organization (WHO) announced that the epidemic situation of Ebola hemorrhagic fever in Congo (DRC) has constituted a public health emergency of international concern, and the risk of epidemic spread has intensified, and the pressure of prevention and control has increased.

  Adrian Xu told reporters that in the first half of this year, the monitoring information of the global infectious disease information monitoring network involved 68 infectious diseases and 140 countries and regions. From the range of occurrence, except influenza, measles, dengue fever, chikungunya fever, cholera and malaria are widely prevalent; According to the degree of harm, pneumonic plague, Ebola hemorrhagic fever, Middle East respiratory syndrome, Lassa fever and Hantavirus lung syndrome are the most common causes of death. In terms of epidemic areas, Ebola hemorrhagic fever, plague, cholera, yellow fever, Lassa fever and rift valley fever are mainly prevalent in Africa, cholera, Middle East respiratory syndrome and dengue fever are mainly prevalent in Asia, and dengue fever and measles are mainly prevalent in America and Europe.

Tens of thousands of infectious diseases were detected.

  Various infectious diseases not only pose a great threat to people’s health and safety, but also have a great impact on social stability and national economy. With the continuous deepening of China’s "Belt and Road" construction and opening up, as well as the accelerated development of global trade, the more convenient transportation network and the more frequent personnel exchanges, human beings have formed a "community of destiny" in the face of epidemic diseases as never before.

  To this end, the national customs has built a port quarantine defense line to prevent the introduction of major epidemics. From January to July this year, 12565 cases of infectious diseases were detected by the national customs entry quarantine.

  On June 10th, the customs staff of Ningbo Airport found that many passengers on a flight from Bangkok had vomiting, diarrhea, abdominal pain and other symptoms. Customs officers immediately carried out on-site investigation and disposal, and found that 15 passengers belonging to the same tour group had symptoms of digestive tract infection. After collecting blood and other samples, the staff issued a convenient card for seeing a doctor and told them to see a doctor as soon as possible before releasing it. On June 14th, Ningbo Health Center reported that three passengers were positive for enterohemolytic Escherichia coli O157:H7. The customs immediately informed the passengers of the test results by telephone, and suggested that they go to the hospital for further review and diagnosis and treatment, and reported the disposal situation to the Ningbo Municipal Government and informed the Ningbo Municipal Health and Health Commission. At the same time, strengthen cooperation with tourism management departments, issue early warnings to travel agencies in a timely manner, and ask the recent travel team to Thailand to pay attention to the relevant epidemic situation and make adjustments to travel routes.

  On July 1st, Kunming Customs found a China male passenger with high body temperature among the people who entered Myanmar at Changshui Airport. On-site staff immediately re-measured the passenger’s body temperature, conducted epidemiological investigation and medical investigation. After investigation, the passenger’s axillary temperature was 37.7℃, accompanied by headache, muscle and joint pain and other symptoms. The staff initially judged that they might be infected with mosquito-borne infectious diseases, so they collected blood samples for inspection at the first time. On July 2, Yunnan Health Center detected that the passenger was positive for Zika virus nucleic acid. The customs immediately informed the patients by telephone, gave them health education and informed the Yunnan Provincial Center for Disease Control and Prevention.

  On July 11th, a flight from Kenya declared to Guangzhou Baiyun Airport Customs that a female passenger from the Democratic Republic of Congo had fever, vomiting and diarrhea during the flight. Customs officers determined that it was a suspicious case of Ebola hemorrhagic fever. The customs will start the joint prevention and control mechanism and emergency plan at the first time, and take protective and disinfection measures; Isolate the passenger, contact the local medical institution to transfer him to another hospital, deliver the sample overnight and start the 24-hour inspection mechanism. The next day, the Health and Quarantine Laboratory (P3) of the Technology Center reported that the suspected Ebola virus disease was excluded.

Prevent and resolve health risks

  "Preventing and resolving major risks is one of the three tough battles established by the 19th National Congress of the Communist Party of China. Specific to the customs health and quarantine work, it is necessary to adhere to the bottom line thinking of preventing major epidemics and strictly controlling the security of the country, and resolutely prevent and resolve the hidden dangers of public health and safety risks at ports." Lin Wei, director of the Health and Quarantine Department of the General Administration of Customs, said.

  In April 2018, in accordance with the unified arrangements for the reform of the party and state institutions, the duties and teams of entry-exit inspection and quarantine management were assigned to the General Administration of Customs. After the institutional reform, the customs has more supervision responsibilities, wider supervision scope and longer supervision chain, and the pressure and challenge of maintaining national security is greater than at any time in history, which puts forward new and higher requirements for customs health and quarantine work.

  In order to prevent the introduction of major epidemic diseases and build a strong port quarantine defense line, the customs health quarantine explored the mode of "moving the border forward", sent elite soldiers and strong generals to carry out epidemic prevention and control abroad, and constantly improved the overseas infectious disease monitoring system. Strict port quarantine inspection, so that every doubt must be investigated and every policeman must be dealt with, improve laboratory testing ability, implement precision quarantine projects, carry out cross-border joint monitoring of vector organisms at key ports, implement port food safety and health supervision and sampling plan, and constantly improve the port health quarantine prevention and control system.

  In order to improve the international travel health service for key groups such as expatriate laborers, the Customs has continuously improved the international travel health service system. In recent years, major epidemics such as Ebola hemorrhagic fever, Middle East respiratory syndrome and Zika virus disease have been properly handled, and the country has been kept. The first case of rhabdovirus infection in China and the second case in the world were detected, and six new viruses, such as yellow fever virus, Zika virus, Rift Valley fever virus, Cooper fever virus and Middle East respiratory syndrome coronavirus, which were not seen in China, were detected, achieving both "absolute quantity" and "gold content" of epidemic detection.

  In order to strengthen supervision, optimize services and actively serve the overall situation of development. The Customs has optimized the examination and approval process for special articles, and the settlement rate reached 95% in 5 days. Implement risk management, strengthen supervision after the event, reduce the burden on enterprises, and support biomedical research and industrial development. Port health permit "two certificates in one", cancel the health permit for storage sites at border ports, and realize the online operation of 13 health and quarantine government services; Excellent completion of G20 summit, APEC meeting, Shanghai Cooperation Summit, Beijing Summit of Forum on China-Africa Cooperation, the first China International Import Expo(CIIE) and other major activities.

  The open ports of 273 countries in China have passed the acceptance of the core competence of port public health, fulfilled the agreement of the International Health Regulations and fulfilled the commitment of China. Ningbo’s experience of "Hong Kong-wide Demonstration City for Health Creation" has been promoted to the whole world by WHO. In addition, the first port public health risk monitoring, early warning and decision-making system has been built to realize comprehensive monitoring, automatic early warning, scientific decision-making and rapid response to global infectious diseases and vectors; It is the largest sanitary treatment scale of large ships in the world. For the first time, the whole ship fumigated a 100,000-ton ship and killed 600,000 live cockroaches.

  Participate in international health governance and give voice to China. The Customs implemented the action of health aid to Africa and promoted the construction of African CDC. Establish the WHO International Health Regulations (Port) Cooperation Center and the International Travel Health Cooperation Center, actively strengthen health and quarantine cooperation with international organizations, neighboring countries and regions, and countries along the Belt and Road, and gradually establish information exchange and joint emergency response mechanisms, so as to contribute "China experience" to international health governance and epidemic prevention and control, and demonstrate "China’s responsibility".

  The relevant person in charge of the General Administration of Customs said that in the next step, the national customs will resolutely implement the spirit of the important instructions of the Supreme Leader General Secretary "Building a port quarantine defense line", adhere to the bottom line thinking, strengthen port epidemic prevention and control and emergency drills, and actively deepen joint prevention and control with departments at all levels to prevent the cross-border spread of infectious diseases and effectively protect people’s lives and health. (Legal Daily reporter Cai Yanhong)

Known as the cheapest electric car, Pentium pony has added an entry-level version, which costs 24,900 yuan. Do you want to buy it?

"Hao Car Attacks" original new car:On August 1st, 2024, FAW added a brand-new model of "Cute Horse" with an official guide price of only 24,900 yuan. The new car is not only a brand-new entry-level model of Pentium Pony, but also a new low starting price of new energy vehicles, even from the perspective of cost performance, which can be regarded as a replacement product of "scooter for the elderly". At the same time, according to the official disclosure, you can still enjoy multiple luxuries when buying a car, including exemption from purchase tax, financial discount on 1000 yuan, giving away compulsory insurance, and renewing the car at a guaranteed price, etc. In addition, there are four lifelong rights and interests worth 6,000 yuan (vehicle lifetime warranty/three-power lifetime warranty/lifetime road rescue and lifetime renewal fund). So what are the highlights of the new car?

Pentium Pony is not only the first model named by numbers in Pentium brand, but also quite different from family-style design styles such as T90 or B70 of Pentium. The rounded headlights are matched with the contrasting body, creating a "kawaii" feeling. At the same time, in order to capture the personalized needs of consumers, the new car also launched a Pentium Pony Gamer Edition or even a convertible version based on the retro style of spliced Ding Mao, including the details of the roof trunk, the integrated spoiler tail and the racing seat. Customized, and the high-profile models are also equipped with LED light sources. In addition, the new car is divided into six body colors to choose from, except Jasmine White. The cost of the selection is 388 yuan (bubble blue/camellia green/peach powder) and 888 yuan (indigo blue/cheese white), which Hao Ge thinks is not expensive.

In terms of interior, the Pentium pony can be described as simple but not simple. Although the price is less than 25,000, it has all the basic functions such as suspended instrument, air conditioning control area, radio and integrated cruise control. The key layout similar to the game console handle style is also particularly fashionable and personalized. It is worth mentioning that the newly added entry-level version of "Cute Horse" is still equipped with common configurations such as air conditioning, airbags, main driver’s cosmetic mirror, ramp assistance and the proportion of rear seats. Compared with the second-lowest cute horse, the only thing missing is the remote control of car Bluetooth and mobile APP, which is why it can be cheaper by 2,000 yuan.

In terms of body size, the length, width and height of the new car are 3000/1510/1630mm, and the wheelbase is 1953mm, which is the same as that of MINI EV (length, width, height and wheelbase are 3064/1493/1629/2010mm, respectively). As a miniature electric vehicle, space performance is naturally not a strong point, but the support ratio of rear seats can still further meet the emergency needs. After all, more convenient parking and narrow road driving ability are the biggest selling points of Pentium pony.

In terms of power, the new car offers two kinds of battery life, 122 km and 170 km. After adding the "cute horse", it happens to have two configurations to choose from. The maximum power of motors is 20 kW (27 HP); 85 nm. The battery is Ferrous lithium phosphate, which only supports slow charging. The 122km version is fully charged in about 5.2 hours, and the 170km version is fully charged in about 6.5 hours. The slow charging port is located at the front logo, with a glass water filling port beside it, and the gear shifting mechanism is knob type.

Summary of "Hao Car Attacks":As we all know, the main competitors of Pentium Pony will be locked into micro electric vehicles such as Wuling Hongguang MINI EV and Geely Panda. Compared with 300,000 ~ 400,000 "luxury" new energy sources in the market, micro-electric vehicles such as Pentium Pony seem to be a clean stream, and at the same time, it is doomed that the most important thing for its audience is high cost performance. The starting price of 24,900 yuan should be the cheapest pure electric vehicle on the market at present, so who would you choose? Thank you for your attention to "Hao Car Attacks".

Hu Manzhi created and shared with you the "messenger" of intercellular communication-cytokines.

The future of cytokine detection is bound to be a red sea. You should know about these clinical applications.

Foreword:

In our bodies, there is a mysterious and powerful system, which always protects us from external pathogens. This system is our immune system, which is composed of many immune cells, like a well-trained army, always ready to resist foreign enemies. In this army, there is a mysterious force playing a role silently, which is cytokine.

Overview of cytokines

Cytokines are a kind of small molecular protein with wide biological activity, which is synthesized and secreted by immune cells (such as monocytes, macrophages, T cells, B cells, NK cells, etc.) and some non-immune cells (such as endothelial cells, epidermal cells, fibroblasts, etc.), and is equivalent to the "messenger" of mutual communication among various cells in human body.

It has many biological functions, such as regulating cell growth, differentiation and maturation, maintaining function, regulating immune response, participating in inflammatory reaction, wound healing and tumor growth and decline.

At present, the detection of cytokines is widely used in infections, kidney diseases, autoimmune diseases, tumors and malignant hematological diseases, which has important clinical significance in the diagnosis of diseases, the judgment of treatment opportunity, the guidance of medication, the monitoring of curative effect, the early warning of cytokine storm risk and the improvement of patients’ treatment efficiency.

Classification and main functions of cytokines

According to their main functions, cytokines can be divided into the following categories: interleukin (ILs), colony stimulating factor (CSFs), interferon (IFNs), tumor necrosis factor (TNFs), growth factor (GFs) and chemokine (CK).

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There are both pro-inflammatory factors and anti-inflammatory factors. Pro-inflammatory factors usually regulate the growth, activation, differentiation and homing of immune cells to infected sites, aiming at controlling and eradicating intracellular pathogens (including viruses); Anti-inflammatory cytokines are a series of immunomodulatory molecules that control the response of pro-inflammatory cytokines.

In the development of infection, the interaction between pro-inflammatory factors and anti-inflammatory factors runs through, which has a far-reaching impact on the development direction and outcome of infection.

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Clinical application value of cytokines

1, early diagnosis of infection, conducive to disease monitoring.

Shortening the window period helps to realize early diagnosis and win valuable time for treatment; The half-life is short, which is convenient to monitor the efficacy in time and ensure the effectiveness and safety of treatment; Complement with PCT and CRP, improve the accuracy of diagnosis and provide strong support for precise treatment.

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Note: In the Expert Consensus on Interpretation of Clinical Significance of Infection-related Biomarkers published in 2017, IL-6 has been regarded as one of the infection-related biomarkers.

2, help to determine the type of infection.

A study showed that IL-6 and IL-10 increased more than 10 times at the same time, suggesting G- bacteria infection; IL-6 increased by 2 times, and IL-10 increased by less than 10 times, suggesting G+ bacteria infection. According to the cytokine spectrum, the effective rate of identifying Gram bacteria to guide antibiotic treatment is close to that of broad-spectrum coverage group, up to 85%, while the effective rate of empirical treatment group is only 60%.

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3. Early warning of cytokine storm

During the period of COVID-19, many critically ill patients suffered from uncontrolled release of cytokines such as IL-6, IL-8, TNF-α, IFN-γ, which led to coagulation storm, thrombosis, myocardial infarction and pulmonary embolism, leading to respiratory failure, organ failure and even death.

Although IL-6 is the key cytokine for everyone at present, it should not be the only one. Cytokines is a huge regulatory network, which is coordinated with each other, constantly changing dynamically and changing with the course of disease.

Therefore, it is suggested that patients at risk of cytokine storm should be jointly tested for cytokines during admission and hospitalization.

4. Assess the inflammation and immune status of the body.

Severe patients may have three inflammatory/immune states: SIRS (Systemic Inflammatory Response Syndrome), CARS (Antagonistic Inflammatory Response Syndrome) and MARS (Mixed Antagonistic Response Syndrome).

When infection or other reasons lead to the imbalance of inflammatory response, if the levels of a large number of proinflammatory factors such as IL-1β, IL-6, IL-8, IL-12, IFN-γ, IFN-α and TNF-α are greatly increased, there is a risk of systemic inflammatory response syndrome -SIRS, and the inflammatory response of the body is strong at this time, so it is recommended to give priority to anti-inflammatory treatment; If the endogenous anti-inflammatory reaction is too strong, the anti-inflammatory factors such as IL-4 and IL-10 will be greatly increased, which indicates the risk of CARS. At this time, the immune function of the body is weak, and it is suggested to strengthen the immune treatment. If both pro-inflammatory factors and anti-inflammatory factors increase significantly, it suggests that the body is a mixed antagonistic response syndrome, suggesting that the body has a strong inflammatory response and low immune function, and it is suggested to carry out anti-inflammatory combined with immune enhancement therapy.

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5. Cytokines and Tumor

Cytokines are the key proteins of signal transmission in tumor microenvironment (TME), which have pleiotropic effects. In terms of anti-tumor, interferon and TGF-β can directly inhibit the growth of tumor cells, while IFN-γ, IL-2, IL-12 and IL-15 can enhance the cytotoxic activity of lymphocytes or bone marrow cells, thus inhibiting cell growth; In promoting tumor, TGF-β, TNF, IL-1β, CXCL12, etc. can promote the survival and proliferation of tumor cells; TNF, IL-6, etc. can cause the disorder of cytokine regulation and promote the occurrence of tumor inflammation; IL-10, IL-4, TGF-β, etc. are immunosuppressed; TNF, IL-6 and various chemokines can also promote angiogenesis.

Studies have confirmed that IL-6, IL-10 and IL-12 are slightly increased, while IL-2, TNF-α and IFN-γ are significantly decreased, suggesting that there may be early tumor microenvironment progress. Early warning of the occurrence of adverse reaction cytokine release syndrome (CRS) caused by PD-1 therapy /CAR-T therapy.

6. Cytokines and Autoimmunity

Hemophagocytic syndrome (HLH):HLH may be caused by persistent antigen stimulation caused by autoimmune diseases or malignant tumors, with high mortality. IL-2R is one of the diagnostic criteria (from China Expert Consensus on Diagnosis and Treatment of Hemophagocytic Syndrome). In addition, the slight increase of IFN-γ, IL-10 and IL-6 can also distinguish HLH from infection, which is helpful for the treatment of HLH patients.

Systemic lupus erythematosus (SLE): As a chronic autoimmune disease, SLE will affect many organ systems, including but not limited to skin, joints and kidneys. Cytokines in active SLE patients, including IL-8, IL-18, IL-6 and IFN-α, were significantly higher than those in inactive SLE patients. Especially, IL-6 and IL-8 showed better sensitivity and specificity than traditional C3, C4 and Anti-dsDNA.

Henoch-Schonlein Purpura (HSP): A large number of studies show that inflammatory cytokines in HSP patients are out of balance, mainly IL-6, IL-8 and TNF-α. When the cutoff value of IL-6 is set to 7 pg/mL, the sensitivity and specificity can reach 78.0% and 80.5%. The change of IL-8 will be greater, which is 2-10 times of the baseline level of healthy people.

7, cytokines and asthma, allergic diseases and lung diseases.

Generally speaking, children’s allergic diseases such as asthma and allergic rhinitis are mainly mediated by humoral immunity (IgE-mediated type I allergy). IL-4 and IL-5 can promote the secretion of IgE antibodies, aggravate allergic diseases, monitor the levels of IL-4 and other proinflammatory factors, and evaluate the condition and efficacy.

In addition, pro-inflammatory cytokines such as IL-6, IL-8 and TNF-α can promote the progress of airway inflammation such as chronic obstructive pulmonary disease (COPD) and pneumonia, and evaluate the changes of cytokine levels, so as to evaluate the disease progress and drug efficacy monitoring of the above diseases.

8. Cytokines and Reproductive Medicine

Studies have proved that Th1 cytokines are significantly increased and Th2 cytokines are decreased in patients with unexplained recurrent abortion. It has also been reported in the literature that the significant increase of IL-22 concentration may be related to unexplained recurrent abortion.

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Advantages and disadvantages of mainstream detection methods for cytokine reagents

1, chemiluminescence method

Advantages: The method is mature and stable in technology, high in sensitivity and wide in linear range, and can efficiently complete single detection in a short time.

Disadvantages: it is impossible to carry out multi-project joint inspection and the sample demand is large, which makes it unable to cope with the large sample size test.

2. Flow fluorescence method

Advantages: As a relatively new detection method, flow fluorescence method stands out for its advantages of realizing multi-item joint inspection with small sample size, especially in large sample size testing, which saves time and cost.

Disadvantages: It may not be as sensitive as the light-emitting platform, and it is difficult to solve the interference problem that may be introduced in the process of multi-joint inspection, which affects the accuracy of its detection to some extent.

3. Enzyme-linked immunosorbent assay

Advantages: The method is mature and stable, with high sensitivity and good stability.

Disadvantages: the reaction time is relatively long, the linear range is narrow, and the detection efficiency is low, so it is more used in scientific research.

Market situation and current situation sharing of cytokine reagents

1. The domestic heat is higher than that of foreign countries.

Through investigation, we found that, for cytokine projects, except IL-6, foreign manufacturers are more respected, and almost no other manufacturers have obtained certificates in China or even CE. At present, only Siemens has obtained the registration certificates for six projects, namely IL-1β, IL-2R, IL-6, IL-8, IL-10 and TNF-α, in China, which is regarded as an early cytokine project company that entered the China market.

The joint inspection of cytokine combination project seems to be a unique project in China, and it is difficult for us to find similar packaged tests in other countries.

From the actual clinical point of view, COVID-19 and sepsis have confirmed the significance of IL-6 detection, and hemophagocytic syndrome has clarified the value of IL-2R detection. However, for other cytokine detection, although everyone is advocating the clinical significance of each index, there is no more recognized expert consensus to explain it. It can only be said that the market prospect is there, but more clinical practice is needed to confirm it.

At present, there are mainly two factions in the detection of cytokines in China, such as the magnetic particle light-emitting platform of Hot Scene Bio, which has obtained the registration certificates of 13 indicators, namely TNF-α, IFN-γ, IL-1β, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-8, IL-10 and IL. At present, the flow fluorescence platform made by Hu Manzhi is generally combined with 12 items, namely TNF-α, IFN-α, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70 and IL-11.

2. Although there are international standards for each project, the testing situation of each manufacturer is not uniform.

Due to the lack of foreign reagents, it seems difficult to maintain the consistency of test results except IL-6. Although almost every project has international standards, from the data of clinical tests, the test results of various manufacturers deviate seriously, and it is difficult to judge which manufacturer’s test value is more accurate. It may be inferred that the traceability chain of each manufacturer is not particularly strict.

We know that most cytokines can’t be stored stably at room temperature, so the general calibrators are in the form of freeze-drying, which may be due to the loss during freeze-drying, or the interference of composite quality control such as flow platform, or the matrix effect introduced in the dilution process of international standards, which makes the test results of reagents difficult to be unified and leads to confusion in clinical judgment.

Market prospect of cytokine detection reagents

Although we have mentioned the problem that various cytokines form a complex network of communication and restriction between cells, there is no disease-specific guidance for many indicators at present, and it is difficult to unify the test results among manufacturers, but on the other hand, it is a huge opportunity for reagent manufacturers. Why do you say that?

First of all, the broad indications of detection indicators mean that cytokine items can be detected in various departments, with a large volume; Moreover, there are not many manufacturers in this testing field, and compared with conventional testing items, the homogenization is not serious and the market prospect is relatively broad; Moreover, the difference in the test results of manufacturers will inevitably lead to the emergence of benchmark enterprises in this field, so many enterprises can establish their own brand image through this product; It is believed that with the further implementation of the consensus of experts in various fields and the gradual maturity of emerging technologies such as flow fluorescence and single molecule detection, cytokine detection will surely be a red sea.

Today’s sharing is here, I hope it will inspire you. (For more information about cytokine detection reagents, please search the official website of HUMAN Zhizhi and click to inquire.)

About Hu manzhizao

Beijing Human Zhizao Technology Co., Ltd. is a medical technology innovation company integrating R&D, production and sales. With years of experience in materials science, in vitro diagnosis technology and marketing, based on the core of multi-flow fluorescence technology, the company is committed to providing fully automatic multi-flow fluorescence detection platform and supporting reagents with competitive advantages for clinical customers, and has built a "new ecology" for ultra-high-speed immunodiagnosis, focusing on major immune diseases, intractable diseases and rare diseases.

Don’t buy the "back from the dead" flowers that are screened by friends!

  Cctv newsRecently, in the circle of friends and the homepages of various social media, many people are drying a flower that can bring life back to life.

  A dead branch without roots.

  Soak it in water for a few days and it will bloom again.

  This kind of dry branch is called "Rhododendron in Daxinganling"

  Is it really that amazing?

  The flowers that came back to life in the circle of friends were warned to destroy the ecological environment.

  The WeChat circle of friends of Ms. Liu, a native of Hangzhou, was screened by this magical "dead wood in spring": "Many people are taking pictures. I also bought one to 20 yuan, which is much cheaper than the flowers in the flower shop. "

  After receiving the dead branch, Ms. Liu put it in the water. In less than two weeks, the branch bloomed with pink and purple flowers, which had a literary beauty. In another week, the flowers have fallen, and young leaves are beginning to come out from the branches, which is a different scenery.

  She exposed this moment of witnessing "miracle" to a circle of friends, but received a dissuasion message from a friend: "Don’t buy this again! This dead branch is broken from wild rhododendron, which will destroy the ecological environment! "

  She is not the only one who received dissuasion messages in the circle of friends. Weibo netizen "Xicheng Green" also said that he was told not to buy this kind of flowers after drying them in a circle of friends.

  Is this true or not? Will it really damage the environment to buy azaleas and raise them at home?

  A bunch of online shops in 20 yuan sell wild rhododendrons.

  The reporter browsed a shopping website, and the pictures below the keywords "Rhododendron hydroponics, dry branches, soaked flowers, dry wood and dead trees meet spring flowers" are all Rhododendron flowers in Xing ‘an, and the store specially added the words "artificial cultivation" and "home planting". Only a few stores still write "dry branches of rhododendron in Xing ‘an" in the product description.

  But the commodity maps are all similar, with pink and purple flowers on the dead branches. People who know a little about flowers can recognize this as azaleas at a glance.

  According to the commodity details of these azaleas, dead branches can bloom in about 7-10 days after being inserted in water and changed once every 3-4 days. If you don’t want it to open for a while, just put the dead branches in the refrigerator for preservation.

  Some stores focus on "wild", and in the product details, they have exposed many photos of flowers and trees in the snowy mountains, as if to prove to buyers that these branches were indeed picked from the mountains.

  According to the customer service of an online shop, these dead branches were imported from the local flower and bird market. People in the market told them that it was wild in the mountains of Daxinganling. As for whether it was true or not, the seller was not sure himself.

  Among these shops selling dead branches, the one with the highest sales volume sells 7,787 orders a month, and the price is 40 sticks in a bunch of 23 yuan. The more you buy, the lower the unit price. In this way, the number of dead branches to be sold every month is not a small number.

  Flowers can bring back the dead? It’s not that amazing!

  Why do dead branches that look lifeless bloom quickly when inserted in water? Experts say that these dead branches are actually not dead at all, just "hibernating"!

  This kind of rhododendron, which grows in Daxing ‘anling and Xiaoxing ‘anling areas, is scientifically called Rhododendron Xing ‘an, also known as Tartar Fragrant, and is the city flower of Yichun City, Heilongjiang Province. It belongs to semi-green shrub, leaves fall and sleep in winter, waiting for the next spring to bloom again. In the dormant period, the branches are broken down, inserted into the water, and then placed in a warm room. The temperature and moisture have reached the conditions for flowering, and the buds on the dead branches naturally bloom.

  This "magical" process can be done not only by cuckoo, but also by branches such as peach blossom and winter jasmine. Therefore, the so-called "coming back to life" is not a "miracle", but just a gimmick of the merchants.

  Expert: wanton logging will destroy the ecological balance.

  However, because of the "magic" stunt, Rhododendron Xing ‘an has been cut down a lot.

  In fact, in 2017, Huzhong District, Daxing ‘anling, Heilongjiang Province issued the Notice on Prohibiting the Collection and Sale of Rhododendron Xing ‘an, because the growth of wild Rhododendron Xing ‘an is slow, only 10 cm long a year, and the rampant deforestation has seriously affected the ecological environment.

   According to experts, the natural environment is a house with balanced distribution. If a large number of azaleas are cut, its ability to absorb sunlight and water will be weakened. This energy will be taken up by other plants, and the cuckoo will only become weaker and weaker.

  In addition, as a woody plant, Rhododendron itself grows slowly, and it takes 5-6 years from sowing to first flowering; If it grows into a branch that can be broken by dozens of centimeters, it is at least twenty or thirty years old. If you want to make it grow back, it will not be so fast.

  Appeal: Don’t pick and buy wild plants.

  Although the local government has taken measures, rhododendrons in Xing ‘an will still be cut and sold in winter.

  Beauty should not be at the expense of injury. I appeal to everyone: don’t buy rhododendron in Xing ‘an, and don’t pick wild plants at will. Let these plants live in their original homes!

  Source: Sichuan Daily WeChat WeChat official account

Baojun responded to Yue brake failure, and software BUG caused brake degradation.

Recently, some car owners posted on social platforms that the brakes of the 2023 smart driving version were abnormal, which attracted the attention of netizens.

On January 4th, Baojun Automobile issued a statement in the official Weibo to respond to the relevant situation. The statement said: "This Yueye incident is not the’ brake failure’ described by the network, but the existence of some vehicles.Software BUG, resulting in the brake assist degradation. This part of the vehicle will enter the speed limit protection state when it is reminded by the indicator light when it is started. "

"After receiving relevant feedback, we intervened in the first time and solved the user’s vehicle problem. Please feel free to use it." Baojun Automobile said, "Without knowing the facts, the relevant media described the words such as’ brake failure’ as inaccurate."

Previously, many car owners reported on social media that the brakes of Baojun Yueye had failed, mainly focusing on the 2023 Baojun Yueye Flagship Edition and Zhizun Edition. The vehicle reported eps code, and the "yellow turtle" fault light appeared on the dashboard. The owner stepped down.brake pedalThe rear vehicle cannot slow down.

A car owner described the problem as follows: "When I was driving on the morning of December 31, 2024, I found that the car slipped after the car was powered on, and there was no response when I stepped on the brakes. I started the car several times without power, and the problem still existed. At the same time, the vehicle dashboard reported the EBS fault light and the drive system fault light, so I called for rescue and dragged the car to the 4s shop for maintenance. So far, the cause of the vehicle problem and the after-sales plan have not been clearly answered."

Stephy’s American-born daughter came back to take a selfie, showing good looks and recovering quickly.

Stephy takes selfies.

Weibo screenshot

    1905 movie network news Recently, Stephy Nathan Scott Lee showed up at Beijing Capital Airport with his daughter, which proved that the whole family had returned to Beijing. At 19: 31 on April 8th, Stephy Weibo took a selfie. In the photo, Stephy took a selfie with a camera in one hand and made an "OK" gesture in the other. Different from the past, the neat short hair has turned into a long hair, which is more charming, and the skin is white and smooth. Postpartum recovery can be called rapid.

    After the exposure of this Weibo, netizens sent blessings one after another, and some netizens ridiculed: "Does this gesture mean a baby brain for three years?"

??

    It is reported that in August 2013, Stephy and American Han Xing Nathan Scott Lee were photographed by the media returning to the apartment together after a barbecue in the middle of the night, and their love affair was open. On August 25th, 2014, Stephy officially announced the wedding news through Weibo, and took a photo with her fiance Nathan Scott Lee. On September 8th, Stephy and Nathan Scott Lee formally married at Caesar Palace Hotel in Las Vegas, USA. On January 17th, 2015, Stephy had a baby girl in Hoag Beach, California. She was nicknamed "Lucky" and weighed 3145g at birth.